10.3.23-Showcase-Osaka-Metanovas_Biotech

LUN YU: [SPEAKING CHINESE] My thought, me-- this is Lun Yu. I'm the co-founder and CTO of Metanovas Biotech. With a PhD degree in nuclear science from MIT, I'm now leading our California-based team in leveraging AI and knowledge graph to develop clinical-grade consumer health products.

When you walk down the aisle of a beauty store or supplement store, you are met with countless products. You may notice a glaring issue. Many of the products don't stand out from each other. And more concerning, many don't have proven clinical benefits. At Metanovas we're changing that.

We believe there are three things we need to focus on, first, deeply understand human biology for informed product development. Second, identify and design ingredients that are not only potent, but also safe for long-term use. And lastly, we need to adopt a systematic approach to solve complex biological problems for true innovations.

At Metanovas we have built four integrated platforms to tackle this. Let me walk you through them one by one. MetaNLP scans millions of scientific documents, converting vast human knowledge into digestible and accessible data. With such data we can navigate specific biological domains easily. MetaKG, our ultra large biomedical knowledge graph, enables us to infer and visualize biological interactions, driving novel discoveries and innovative product development.

With MetaOmics, we harness multi-omics data for targeted precision products tailored for specific demographics. And lastly, our MetaPep platform merges deep learning and molecular simulations for peptide designs. It rapidly designs bioactive peptides with impressive success rate.

While individual platforms might be found elsewhere, we are pioneers in integrating all of them for end-to-end holistic development. Our platforms have been extensively used in biological understanding, ingredient discovery and design, and product development. The unique values we offer to our clients include better product strategies from novel biological insights, proven clinical efficacy from our bioactive peptides and ingredient combinations, unique product offerings and brand positioning from precision product development, and science-driven marketing storytelling by assembling various kinds of scientific evidence. Our current clients include biopharmaceutical companies, established consumer brands, and emerging consumer brands, both globally and locally as listed here.

Next let me demonstrate two success stories at Metanovas using our technologies. With leveraging our MetaKG platform, we designed the world's first AI-designed skincare solutions for vascular type under-eye dark circle, which is prevalent in Asian women. We began the process by identifying the key biological processes behind this issue, and then we navigate the knowledge graph to predict novel natural products targeting the underlying genes.

A third party trial confirmed this efficacy with 93% of users noting reduced pigmentation in just 14 days. With the MetaPep platform, we crafted unique novel peptides with dual functions, antimicrobial and anti-inflammatory functions. It targets the TLR2 proteins and curbing the nitric oxide production and pro-inflammatory cytokine release during skin inflammation. It also combats the C acne bacteria, which is the primary acne culprit. A third party trial also verified its power, showing reduced acne spots in seven days, and 90% of the respondents witnessing acne improvement.

I believe our stories have demonstrated our expertise and strength. Now we invite you to work with us. In Asia we have unique business focuses. We focus on Asian ingredients, especially mining the hidden gems in Chinese, Japanese, and Korean traditional medicine, and combine them with the bioactive peptides for enhanced efficacy. We appreciate our Asian distinction and are passionate about developing unique products for Asian consumers. Since our foundations, we have worked with numerous Asian brands.

We would love to leverage our experience and insights to serve our Japanese clients. We take pride in Asian innovations and would love to bring them to the world. That's why we also have clients with a global presence, to help us transcend the national boundaries. We offer three types of services, technical solutions where we offer technical consulting for biological discovery, ingredient selection, and product development.

We also work with our clients to co-develop novel and unique ingredients and products, where we also take royalty shares from the sales. If you're just looking for a unique ingredient or efficacious ingredient, we also offer direct ingredient sales to meet your product requirements. No matter you are a pharma company, cosmeceutical companies, or nutraceutical companies we look forward to bringing tangible values to your product innovations. We're Metanovas. Your next breakthrough will start with us.

[SPEAKING CHINESE]